Drug Design Concept in Ocular Drug Delivery

Ocular administration of the drug is primarily associated with the need to treat ophthalmic diseases and is not regarded as a means for gaining systemic drug action. Major classes of drugs used are miotics, mydriatics/cyclopegics, anti-inflammatory, antiinfectives, surgical adjutants and diagnostics, which are all meant for local therapy. Systemic action by using eye as a portal is generally avoided in order to prevent the risk of eye damage from high blood concentrations of drug not intended for eye. The unique anatomy, physiology and biochemistry of eye render this organ exquisitely impervious to for gain substances thus presenting a constant challenge to the formulator to circumvent the protective barriers of the eye without causing any permanent tissue damage. Currently, the knowledge in this field is rapidly expanding, and many concept and drug delivery strategies are emerging out.